Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients

• DOI: 10.1126/scitranslmed.3003401
• Publication Date: 2012-01-26T05:23:13Z
• Authors: Frank Waldron-Lynch; Octavian Henegariu; Songyan Deng; Paula Preston-Hur...; James Tooley; Richard Flavell; Kevan C. Herold
• Keywords: Humanized mouse

Humanized mice can be successfully used as a preclinical testing platform to identify the mechanism of action immunotherapies in humans.