Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients

• DOI: 10.1126/scitranslmed.3003578
• Publication Date: 2012-06-13T19:09:47Z
• Authors: Robert A. Adair; Victoria Roulstone; Karen J. Scott; Ruth Morgan; Gerard J. Nuovo; Martin Fuller; Deborah Beirne; Emma J. West; Victoria A. Jennings; Ailsa Rose; Joan Kyula; Sheila Fraser; Rajiv Dave; David A. Anthoney; Alison Merrick; Robin Prestwich; Amer Aldouri; Oliver Donnelly; Hardev Pandha; Matt Coffey; Peter Selby; Richard Vile; Giles Toogood; Kevin Harrington; Alan A. Melcher
• Keywords: Blood Platelets; Male; Oncolytic Virotherapy; 0303 health sciences; Liver Neoplasms; Genome, Viral; Middle Aged; Virus Replication; Antibodies, Neutralizing; 3. Good health; Oncolytic Viruses; 03 medical and health sciences; Humans; Female; Colorectal Neoplasms; Aged; Granulocytes

Oncolytic reovirus is carried by cells to tumors and protected from neutralizing antibodies in the circulation.