DNAzyme Targeting c- jun Suppresses Skin Cancer Growth

• DOI: 10.1126/scitranslmed.3003960
• Publication Date: 2012-06-20T21:59:00Z
• Authors: Hong Cai; Fernando S. Santiago; Leonel Prado-Lour...; Bo Wang; Margaret Patrikakis; Miles P. Davenport; Ghassan J. Maghzal; Roland Stocker; Christopher R. Pa...; Beng H. Chong; Graham J. Lieschke; Tak-Wah Wong; Colin N. Chesterman; Douglas J. Francis; Fergal J. Moloney; Ross St.C. Barnetson; Gary M. Halliday; Levon M. Khachigian
• Keywords: Keywords: 1,2 dioleoyl 3 trimethylammoniopropane; 0301 basic medicine; Skin Neoplasms; protein c jun; Proto-Oncogene Proteins c-jun; animal experiment; Apoptosis; animal cell; antineoplastic activity; animal tissue; Mice; 03 medical and health sciences; Cell Line, Tumor; Animals; Humans; antineoplastic agent; Zebrafish; Immunity, Cellular; Dose-Response Relationship, Drug; dz 13; messenger RNA; animal model; DNA, Catalytic; unclassified drug; apopto; 3. Good health; deoxyribozyme

Catalytic DNA molecules that target the transcription factor c- jun inhibit skin cancer growth in mice.