Targeting Cancer with a Lupus Autoantibody

• DOI: 10.1126/scitranslmed.3004385
• Publication Date: 2012-10-24T18:30:03Z
• Authors: James E. Hansen; Grace Chan; Yanfeng Liu; Denise C. Hegan; Shibani Dalal; Eloise Dray; Youngho Kwon; Yuanyuan Xu; Xiaohua Xu; Elizabeth Peterso...; Erik Geiger; Yilun Liu; Joseph Gera; Joann B. Sweasy; Patrick Sung; Sara Rockwell; Robert N. Nishimura; Richard H. Weisbart; Peter M. Glazer
• Keywords: BRCA2 Protein; 0301 basic medicine; DNA Repair; Brain Neoplasms; 610; DNA, Single-Stranded; Mice, Nude; General Medicine; Glioma; Xenograft Model Antitumor Assays; 3. Good health; Mice; 03 medical and health sciences; 2700 Medicine; Cell Line, Tumor; 616; Animals; Humans; Lupus Erythematosus, Systemic; Female; Autoantibodies; DNA Damage; Protein Binding; Single-Chain Antibodies

A cell-penetrating lupus anti-DNA antibody inhibits DNA repair, sensitizes cancer cells to DNA-damaging therapy in vitro and vivo, is synthetically lethal BRCA2-deficient human cells.