Ser 1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

• DOI: 10.1126/scitranslmed.3004485
• Publication Date: 2012-12-12T19:22:16Z
• Authors: Zejuan Sheng; Shuo Zhang; Daisy Bustos; Tracy Kleinheinz; Claire E. Le Pichon; Sara L. Dominguez; Hilda O. Solanoy; Jason Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P. van der...; Daniel J. Burdick; Janet Gunzner-Toste; Huifen Chen; Xingrong Liu; Anthony A. Estrada; Zachary K. Sweeney; Kimberly Scearce-...; John G. Moffat; Donald S. Kirkpat...; Haitao Zhu
• Keywords: LRRK2

LRRK2 autophosphorylation on Ser 1292 may be a useful indicator of kinase activity, providing readout for screening candidate inhibitors.