Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

• DOI: 10.1126/scitranslmed.3005723
• Publication Date: 2013-05-22T18:25:10Z
• Authors: Sophie Rousseaux; Alexandra Debernardi; Baptiste Jacquiau; Anne-Laure Vitte; Aurélien Vesin; Hélène Nagy-Mignotte; Denis Moro-Sibilot; Pierre-Yves Brichon; Sylvie Lantuejoul; Pierre Hainaut; Julien Laffaire; Aurélien de Reyniès; David G. Beer; Jean-François Timsit; Christian Brambilla; Elisabeth Brambilla; Saadi Khochbin
• Keywords: Animals Cell Line; 0301 basic medicine; Lung Neoplasms; Placenta; Epigenesis, Genetic; 03 medical and health sciences; Pregnancy; Cell Line, Tumor; Animals; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Genetic/genetics Reproducibility of Results Transcriptome; Promoter Regions, Genetic; Neoplasm Staging; Neoplastic Germ Cells/*metabolism Humans Lung Neoplasms/drug therapy/*genetics/*pathology Neoplasm Invasiveness Neoplasm Metastasis/genetics Neoplasm Staging Organ Specificity Placenta/*metabolism Pregnancy Prognosis Promoter Regions; Reproducibility of Results; DNA Methylation; Prognosis; 3. Good health; Gene Expression Regulation, Neoplastic; Germ Cells; [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie; Organ Specificity; Female; Genetic Female *Gene Expression Regulation; Tumor DNA Methylation/genetics Epigenesis; Transcriptome

Large-scale detection of ectopic gene activations reveals a source potential cancer biomarkers and correlates with aggressive metastasis-prone lung tumors.