Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

• DOI: 10.1126/scitranslmed.3005795
• Publication Date: 2013-07-17T18:41:14Z
• Authors: Federico Mingozzi; Xavier M. Anguela; Giulia Pavani; Yifeng Chen; Robert J. Davidson; Daniel J. Hui; Mustafa Yazicioglu; Liron Elkouby; Christian J. Hind...; Armida Faella; Carolann Howard; Alex Tai; Gregory M. Podsakoff; Shangzhen Zhou; Etiena Basner-Tsc...; John Fraser Wright; Katherine A. High
• Keywords: Humoral immunity

Capsid decoys enhance the efficacy of AAV vector transduction after systemic delivery in presence neutralizing antibodies.