Vitamin D Deficiency Induces Early Signs of Aging in Human Bone, Increasing the Risk of Fracture

• DOI: 10.1126/scitranslmed.3006286
• Publication Date: 2013-07-10T18:15:45Z
• Authors: Björn Busse; Hrishikesh A. Bale; Elizabeth A. Zimm...; Brian Panganiban; Holly D. Barth; Alessandra Carriero; Eik Vettorazzi; Josef Zustin; Michael Hahn; Joel W. Ager; Klaus Püschel; Michael Amling; Robert O. Ritchie
• Keywords: Male; 0301 basic medicine; Aging; Spectrum Analysis; X-Ray Microtomography; Vitamin D Deficiency; Bone and Bones; Biomechanical Phenomena; Fractures, Bone; 03 medical and health sciences; Bone Density; Risk Factors; Humans; Female; Collagen; Disease Susceptibility; Synchrotrons

In addition to decreasing bone mass, vitamin D deficiency causes early aging of the remaining mineralized bone and leads to severe losses in fracture resistance.