Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

• DOI: 10.1126/scitranslmed.3007094
• Publication Date: 2014-02-19T19:15:49Z
• Authors: Chetan Bettegowda; Mark Sausen; Rebecca J. Leary; Isaac Kinde; Yuxuan Wang; Nishant Agrawal; Bjarne R. Bartlett; Hao Wang; Brandon Luber; Rhoda M. Alani; Emmanuel S. Anton...; Nilofer S. Azad; Alberto Bardelli; Henry Brem; John L. Cameron; Clarence C. Lee; Leslie A. Fecher; Gary L. Gallia; Peter Gibbs; Dung Le; Robert L. Giuntoli; Michael Goggins; Michael D. Hogarty; Matthias Holdhoff; Seung-Mo Hong; Yuchen Jiao; Hartmut H. Juhl; Jenny J. Kim; Giulia Siravegna; Daniel A. Laheru; Calogero Lauricella; Michael Lim; Evan J. Lipson; Suely Kazue Nagah...; George J. Netto; Kelly S. Oliner; Alessandro Olivi; Louise Olsson; Gregory J. Riggins; Andrea Sartore-Bi...; Kerstin Schmidt; le-Ming Shih; Sueli Mieko Oba-S...; Salvatore Siena; Dan Theodorescu; Jeanne Tie; Timothy T. Harkins; Silvio Veronese; Tian-Li Wang; Jon D. Weingart; Christopher L. Wo...; Laura D. Wood; Dongmei Xing; Ralph H. Hruban; Jian Wu; Peter J. Allen; C. Max Schmidt; Michael A. Choti; Victor E. Velculescu; Kenneth W. Kinzler; Bert Vogelstein; Nickolas Papadopo...; Luis A. Diaz
• Keywords: Adult; Aged, 80 and over; Male; DNA, Neoplasm; Middle Aged; circulating tumor DNA; detection; CANCER; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Adult; Aged; Aged, 80 and over; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Young Adult; Medicine (all); Neoplasms; Humans; Female; Neoplasm Metastasis; Aged

Circulating tumor DNA can be used in a variety of clinical and investigational settings across tumor types and stages for screening, diagnosis, and identifying mutations responsible for therapeutic response and drug resistance.