The HMGB1-RAGE axis mediates traumatic brain injury–induced pulmonary dysfunction in lung transplantation

• DOI: 10.1126/scitranslmed.3009443
• Publication Date: 2014-09-04T14:13:34Z
• Authors: Daniel J. Weber; Adam S. A. Gracon; Matthew S. Ripsch; Amanda J. Fisher; Bo M. Cheon; Pankita H. Pandya; Ragini Vittal; Maegan L. Capitano; Youngsook Kim; Yohance M. Allette; Amanda A. Riley; Brian P. McCarthy; Paul R. Territo; Gary D. Hutchins; Hal E. Broxmeyer; George E. Sandusky; Fletcher A. White; David S. Wilkes
• Keywords: HMGB1; RAGE

Traumatic brain injury induces acute lung that negatively impacts the physiology of donor before and after transplantation.