Imaging Enterobacteriaceae infection in vivo with 18 F-fluorodeoxysorbitol positron emission tomography

• DOI: 10.1126/scitranslmed.3009815
• Publication Date: 2014-10-27T04:23:24Z
• Authors: Edward A. Weinstein; Alvaro A. Ordonez; Vincent P. DeMarco; Allison M. Murawski; Supriya Pokkali; Elizabeth M. MacD...; Mariah Klunk; Ronnie C. Mease; Martin G. Pomper; Sanjay K. Jain
• Keywords: Inflammation; Myositis; Brain Neoplasms; Enterobacteriaceae Infections; Microbial Sensitivity Tests; Xenograft Model Antitumor Assays; Cell Line; Klebsiella Infections; 3. Good health; Radiography; Klebsiella pneumoniae; Mice; Anti-Infective Agents; Positron-Emission Tomography; Escherichia coli; Animals; Humans; Sorbitol; Female; Immunocompetence

2-[ 18 F]-Fluorodeoxysorbitol, a synthetic PET probe, can be used to rapidly, sensitively, and specifically image Gram-negative bacterial infections in animals.