Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia

• DOI: 10.1126/scitranslmed.aaa1616
• Publication Date: 2015-01-28T19:16:19Z
• Authors: Nuria Oliva; Maria Carcole; Margarita Beckerman; Sivan Seliktar; Alison Hayward; James Stanley; Nicola Maria Anne...; Elazer R. Edelman; Natalie Artzi
• Keywords: Biocompatibility; Biomaterial; Tissue Adhesion

A "one material fits all" mindset ignores profound differences in target tissues that affect their responses and reactivity. Yet little attention has been paid to the role of diseased tissue on performance, biocompatibility, healing capacity. We assessed material-tissue interactions with a prototypical adhesive based dendrimer/dextran colon as model platform. Adhesive materials have high sensitivity changes environment can be exploited probe quantify influence even subtle modifications architecture biology. studied inflammatory colitis cancer found not only difference adhesion related surface chemical but also existence complex interplay determined overall biomaterial compatibility. Compatibility was contextual, simply constitutive property material, extent nature immune cells present before implantation. then showed how use information about local alterations microenvironment assess disease severity. This turn guided us an optimal formulation choice using predictive clinically relevant conditions.