Vitamin D–dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma

• DOI: 10.1126/scitranslmed.aaa3230
• Publication Date: 2015-04-08T18:11:28Z
• Authors: Heiko Bruns; Maike Büttner; Mario Fabri; Dimitrios Mougiak...; Jörg T. Bittenbring; Markus H. Hoffmann; Fabian Beier; Shirin Pasemann; Regina Jitschin; Andreas D. Hofmann; Frank Neumann; Christoph Daniel; Anna Maurberger; Bettina Kempkes; Kerstin Amann; Andreas Mackensen; Armin Gerbitz
• Keywords: Lymphoma, B-Cell; Cell Death; Macrophages; Antibody-Dependent Cell Cytotoxicity; Mitochondria; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cathelicidins; Humans; Vitamin D; Antimicrobial Cationic Peptides; Cell Proliferation

Vitamin D promotes tumoricidal activity of macrophages and improves the efficacy of antibody-dependent cellular cytotoxicity.