PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

• DOI: 10.1126/scitranslmed.aaa4442
• Publication Date: 2015-04-15T18:15:00Z
• Authors: Ana Bosch; Zhiqiang Li; Anna Bergamaschi; Haley Ellis; Eneda Toska; Aleix Prat; Jessica J. Tao; Daniel E. Spratt; Nerissa T. Viola-...; Pau Castel; Gerard Minuesa; Natasha Morse; Jordi Rodón; Yasir Ibrahim; Javier Cortes; Jose Perez-Garcia; Patricia Galvan; Judit Grueso; Marta Guzman; John A. Katzenell...; Michael Kharas; Jason S. Lewis; Maura Dickler; Violeta Serra; Neal Rosen; Sarat Chandarlapaty; Maurizio Scaltriti; José Baselga
• Keywords: Estrogen receptor alpha; Estrogen receptor beta

Inhibition of the PI3K/AKT pathway results in induction ER-dependent transcriptional activity and susceptibility to anti-estrogen therapy ER-positive breast cancer.