Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

• DOI: 10.1126/scitranslmed.aaa4616
• Publication Date: 2015-05-20T18:20:10Z
• Authors: Karen M. Doody; Stephanie M. Stan...; Cristiano Sacchetti; Mattias N. D. Sve...; Charlotte H. Coles; Nikolaos Mitakidis; William B. Kiosses; Beatrix Bartok; Camille Fos; Esther Cory; Robert L. Sah; Ru Liu-Bryan; David L. Boyle; Heather A. Arnett; Tomas Mustelin; Maripat Corr; Jeffrey D. Esko; Michel L. Tremblay; Gary S. Firestein; A. Radu Aricescu; Nunzio Bottini
• Keywords: 0301 basic medicine; Time Factors; Medical Biotechnology; deficiency [Receptor-Like Protein Tyrosine Phosphatases, Class 2]; Receptor-Like Protein Tyrosine Phosphatases; metabolism [Syndecan-4]; Medical and Health Sciences; metabolism [Cytoskeletal Proteins]; Severity of Illness Index; PTPRS protein, human; Arthritis, Rheumatoid; Mice; Cell Movement; Rheumatoid; drug effects [Cell Adhesion]; analogs & derivatives [Heparin]; 2.1 Biological and endogenous factors; Minority Health; Molecular Targeted Therapy; Aetiology; Phosphorylation; drug effects [Cell Movement]; Mice, Knockout; metabolism [Proteoglycans]; Synovial Membrane; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Biological Sciences; 3. Good health; Health Disparities; 5.1 Pharmaceuticals; drug effects [Synovial Membrane]; Antirheumatic Agents; immunology [Synovial Membrane]; pharmacology [Antirheumatic Agents]; SDC4 protein, human; Proteoglycans; ddc:500; Biomedical engineering; Signal Transduction; drug effects [Signal Transduction]; Knockout; Medical biotechnology; 610; Rheumatoid Arthritis; Transfection; Autoimmune Disease; pathology [Synovial Membrane]; Ptprs protein, mouse; 03 medical and health sciences; Clinical Research; genetics [Syndecan-4]; metabolism [Receptor-Like Protein Tyrosine Phosphatases, Class 2]; Cell Adhesion; Animals; Humans; enzymology [Arthritis, Rheumatoid]; enzymology [Synovial Membrane]; immunology [Arthritis, Rheumatoid]; metabolism [Heparin]; Biomedical and Clinical Sciences; antagonists & inhibitors [Receptor-Like Protein Tyrosine Phosphatases, Class 2]; Animal; Heparin; Arthritis; Inflammatory and immune system; genetics [Receptor-Like Protein Tyrosine Phosphatases, Class 2]; pathology [Arthritis, Rheumatoid]; Class 2; heparin proteoglycan; Sdc4 protein, mouse; prevention & control [Arthritis, Rheumatoid]; ezrin; Cytoskeletal Proteins; Disease Models, Animal; HEK293 Cells; Chondroitin Sulfate Proteoglycans; Musculoskeletal; Disease Models; Women's Health; Syndecan-4; metabolism [Chondroitin Sulfate Proteoglycans]

Targeting joint-lining fibroblast-like synoviocytes reduces the severity of arthritis.