Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes

• DOI: 10.1126/scitranslmed.aac6336
• Publication Date: 2015-12-23T19:43:44Z
• Authors: M. Furkan Burak; Karen E. Inouye; Ariel White; Alexandra Lee; Gurol Tuncman; Ediz S. Calay; Motohiro Sekiya; Amir Tirosh; Kosei Eguchi; Gabriel Birrane; Daniel Lightwood; Louise Howells; Geofrey Odede; Hanna Hailu; Shauna West; Rachel Garlish; Helen Neale; Carl Doyle; Adrian Moore; Gökhan S. Hotamis...
• Keywords: Male; 0301 basic medicine; Antibodies, Monoclonal; Mice, Obese; Diet, High-Fat; Fatty Acid-Binding Proteins; 3. Good health; Fatty Liver; Mice, Inbred C57BL; 03 medical and health sciences; Glucose; Adipose Tissue; Diabetes Mellitus, Type 2; Body Composition; Metabolome; Animals; Humans; Insulin; Amino Acid Sequence

A monoclonal antibody to fatty acid–binding protein aP2 has antidiabetic effects on glucose output and utilization.