USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

• DOI: 10.1126/scitranslmed.aad0015
• Publication Date: 2016-01-27T19:53:13Z
• Authors: Pirkka-Pekka Laurila; Jarkko Soronen; Sander Kooijman; Saara Forsström; Mariëtte R. Boon; Ida Surakka; Essi Kaiharju; Claudia P. Coomans; Sjoerd A. A. Van ...; Anu Autio; Antti-Pekka Sarin; Johannes Kettunen; Emmi Tikkanen; Tuula Manninen; Jari Metso; Reija Silvennoinen; Krista Merikanto; Maija Ruuth; Julia Perttilä; Anne Mäkelä; Ayaka Isomi; Anita M. Tuomainen; Anna Tikka; Usama Abo Ramadan; Ilkka Seppälä; Terho Lehtimäki; Johan Eriksson; Aki Havulinna; Antti Jula; Pekka J. Karhunen; Veikko Salomaa; Markus Perola; Christian Ehnholm; Miriam Lee-Rueckert; Miranda Van Eck; Anne Roivainen; Marja-Riitta Task...; Leena Peltonen; Eero Mervaala; Anu Jalanko; Esa Hohtola; Vesa M. Olkkonen; Samuli Ripatti; Petri T. Kovanen; Patrick C. N. Rensen; Anu Suomalainen; Matti Jauhiainen
• Keywords: Adult; Blood Glucose; 0301 basic medicine; Cholesterol, HDL; Carbohydrates; ta3121; Lipoproteins, VLDL; Atherosclerosis; Cardiovascular System; Lipids; 3. Good health; Cohort Studies; Lipoprotein Lipase; 03 medical and health sciences; Glucose; Adipose Tissue, Brown; Liver; Animals; Humans; Insulin; Female; Gene Silencing; Alleles; Aged

Deficiency of USF1 protects against obesity, insulin resistance, and cardiovascular disease in mice and humans, and induces brown adipose tissue to burn triglycerides and glucose.