The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

• DOI: 10.1126/scitranslmed.aad3099
• Publication Date: 2016-05-18T18:13:24Z
• Authors: Gabriela Brumatti; Chunyan Ma; Najoua Lalaoui; Nhu-Y Nguyen; Mario Navarro; Maria C. Tanzer; Jennifer Richmond; Margherita Ghisi; Jessica M. Salmon; Natasha Silke; Giovanna Pomilio; Stefan P. Glaser; Elisha de Valle; Raffi Gugasyan; Mark A. Gurthridge; Stephen M. Condon; Ricky W. Johnstone; Richard Lock; Guy Salvesen; Andrew Wei; David L. Vaux; Paul G. Ekert; John Silke
• Keywords: Caspase 8; Indoles; Intracellular Signaling Peptides and Proteins; Apoptosis; Drug Synergism; Dipeptides; Caspase Inhibitors; 3. Good health; Leukemia, Myeloid, Acute; Necrosis; Drug Resistance, Neoplasm; Cell Line, Tumor; Tumor Cells, Cultured; Humans; Pentanoic Acids

The combination of a SMAC mimetic and a caspase inhibitor kills AML cells by inducing necroptosis.