Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

• DOI: 10.1126/scitranslmed.aad4059
• Publication Date: 2016-05-25T18:13:36Z
• Authors: Trevor T. Price; Monika L. Burness; Ayelet Sivan; Matthew J. Warner; Renee Cheng; Clara H. Lee; Lindsey Olivere; Karrie Comatas; John Magnani; H. Kim Lyerly; Qing Cheng; Chad M. McCall; Dorothy A. Sipkins
• Keywords: 0301 basic medicine; Benzylamines; Microscopy, Confocal; Breast Neoplasms; Mice, SCID; Cyclams; Flow Cytometry; Immunohistochemistry; Chemokine CXCL12; 3. Good health; Mice; 03 medical and health sciences; Bone Marrow; Heterocyclic Compounds; Neoplasm Micrometastasis; Cell Line, Tumor; MCF-7 Cells; Animals; Humans; Female; Neoplasm Recurrence, Local; E-Selectin; Protein Binding

Breast cancer cells traffic to and from the peripheral blood within specific vascular niches, this migration can be therapeutically targeted.