Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

• DOI: 10.1126/scitranslmed.aad9735
• Publication Date: 2017-04-26T18:20:25Z
• Authors: Tanya Paquet; Claire Le Manach; Diego González Ca...; Yassir Younis; Philipp P. Henrich; Tara S. Abraham; Marcus C. S. Lee; Rajshekhar Basak; Sonja Ghidelli-Disse; María José Lafuen...; Marcus Bantscheff; Andrea Ruecker; Andrew M. Blagbor...; Sara E. Zakutansky; Anne-Marie Zeeman; Karen L. White; David M. Shackleford; Janne Mannila; Julia Morizzi; Christian Scheurer; Iñigo Angulo-Bart...; María Santos Mart...; Santiago Ferrer; Laura María Sanz; Francisco Javier ...; Janette Reader; Mariette Botha; Koen J. Dechering; Robert W. Sauerwein; Anchalee Tungtaeng; Pattaraporn Vanac...; Chek Shik Lim; Jeremy Burrows; Michael J. Witty; Kennan C. Marsh; Christophe Bodenr...; Rosemary Rochford; Suresh M. Solapure; María Belén Jimén...; Sergio Wittlin; Susan A. Charman; Cristina Donini; Brice Campo; Lyn-Marie Birkholtz; Kirsten K. Hanson; Gerard Drewes; Clemens H. M. Kocken; Michael J. Delves; Didier Leroy; David A. Fidock; David Waterson; Leslie J. Street; Kelly Chibale
• Keywords: Plasmodium (life cycle)

MMV390048, a member of new class inhibitors the Plasmodium phosphatidylinositol 4-kinase, shows potential for both treatment and prophylaxis.