Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

• DOI: 10.1126/scitranslmed.aad9922
• Publication Date: 2016-03-09T20:02:40Z
• Authors: Taylor S. Cohen; Jamese J. Hilliard; Omari Jones-Nelson; Ashley E. Keller; Terrence O’Day; Christine Tkaczyk; Antonio DiGiandom...; Melissa Hamilton; Mark Pelletier; Qun Wang; Binh An Diep; Vien T. M. Le; Lily Cheng; JoAnn Suzich; C. Kendall Stover; Bret R. Sellman
• Keywords: 0303 health sciences; Microbial Viability; Calpain; Coinfection; Neutrophils; Bacterial Toxins; Antibodies, Monoclonal; Pneumonia; Opportunistic Infections; Antibodies, Bacterial; Models, Biological; 3. Good health; Enzyme Activation; Killer Cells, Natural; Hemolysin Proteins; Mice; 03 medical and health sciences; Macrophages, Alveolar; Pseudomonas aeruginosa; Animals; Humans; Lysosomes; Acids

S. aureus α toxin promotes opportunistic co-infection, which can be neutralized with a pathogen-specific antibody.