Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

• DOI: 10.1126/scitranslmed.aaf2304
• Publication Date: 2016-08-17T18:50:12Z
• Authors: Fuqin Fan; Zhixiang He; Lu-Lu Kong; Qinghua Chen; Quan Yuan; Shihao Zhang; Jinjin Ye; Hao Liu; Xiufeng Sun; Jing Geng; Lunzhi Yuan; Lixin Hong; Chen Xiao; Weiji Zhang; Xihuan Sun; Yunzhan Li; Ping Wang; Lihong Huang; Xinrui Wu; Zhiliang Ji; Qiao Wu; Ning-Shao Xia; Nathanael S. Gray; Lanfen Chen; Cai-Hong Yun; Xianming Deng; Dawang Zhou
• Keywords: Hippo signaling pathway; Tissue Repair

Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor kinase MST1/2 provides therapeutic option for tissue injury repair.