A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

• DOI: 10.1126/scitranslmed.aai7635
• Publication Date: 2017-12-20T19:14:04Z
• Authors: Katie J. Ryan; Charles C. White; Kruti Patel; Jishu Xu; Marta Olah; Joseph M. Replogle; Michael Frangieh; Maria Cimpean; Phoebe Winn; Allison McHenry; Belinda J. Kaskow; Gail Chan; Nicole Cuerdon; David A. Bennett; Justin D. Boyd; Jaime Imitola; Wassim Elyaman; Philip L. De Jager; Elizabeth M. Brad...
• Keywords: 0303 health sciences; Genotype; Quantitative Trait Loci; Sialic Acid Binding Ig-like Lectin 3; Cell Polarity; Genetic Variation; Models, Biological; Polymorphism, Single Nucleotide; Monocytes; 03 medical and health sciences; Phenotype; Gene Expression Regulation; Nerve Degeneration; Humans; Protein Isoforms; Genetic Predisposition to Disease; Microglia; Genome-Wide Association Study

A microglial-like cellular model can be used to identify functional consequences of genetic variants associated with neurodegenerative disease.