Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

• DOI: 10.1126/scitranslmed.aai7795
• Publication Date: 2018-01-10T19:05:38Z
• Authors: Ken Y. Hui; Heriberto Fernand...; Jianzhong Hu; Adam Schaffner; Nathan Pankratz; Nai-Yun Hsu; Ling-Shiang Chuang; Shai Carmi; Nicole Villaverde; Xianting Li; Manual Rivas; Adam P. Levine; Xiuliang Bao; Philippe R. Labrias; Talin Haritunians; Darren Ruane; Kyle Gettler; Ernie Chen; Dalin Li; Elena R. Schiff; Nikolas Pontikos; Nir Barzilai; Steven R. Brant; Susan Bressman; Adam S. Cheifetz; Lorraine N. Clark; Mark J. Daly; Robert J. Desnick; Richard H. Duerr; Seymour Katz; Todd Lencz; Richard H. Myers; Harry Ostrer; Laurie Ozelius; Haydeh Payami; Yakov Peter; John D. Rioux; Anthony W. Segal; William K. Scott; Mark S. Silverberg; Jeffery M. Vance; Iban Ubarretxena-...; Tatiana Foroud; Gil Atzmon; Itsik Pe’er; Yiannis Ioannou; Dermot P. B. McGo...; Zhenyu Yue; Eric E. Schadt; Judy H. Cho; Inga Peter
• Keywords: LRRK2

Crohn’s disease (CD)–associated variants in the LRRK2 gene for risk (N2081D) and protection (N551K) mediate shared effects CD Parkinson’s disease.