Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

• DOI: 10.1126/scitranslmed.aai8504
• Publication Date: 2018-01-03T22:17:04Z
• Authors: Claire Vennin; Venessa T. Chin; Sean C. Warren; Morghan C. Lucas; David Herrmann; Astrid Magenau; Pauline Melenec; Stacey N. Walters; Gonzalo del Monte...; James R. W. Conway; Max Nobis; Amr H. Allam; Rachael A. McCloy; Nicola Currey; Mark Pinese; Alice Boulghourjian; Anaiis Zaratzian; Arne A. S. Adam; Celine Heu; Adnan M. Nagrial; Angela Chou; Angela Steinmann; Alison Drury; Danielle Froio; Marc Giry-Laterriere; Nathanial L. E. H...; Tri Phan; Rohit Jain; Wolfgang Weninger; Ewan J. McGhee; Renee Whan; Amber L. Johns; Jaswinder S. Samra; Lorraine Chantrill; Anthony J. Gill; Maija Kohonen-Corish; Richard P. Harvey; Andrew V. Biankin; ; T. R. Jeffry Evans; Kurt I. Anderson; Shane T. Grey; Christopher J. Or...; David Gallego-Ortega; Yingxiao Wang; Michael S. Samuel; Owen J. Sansom; Andrew Burgess; Thomas R. Cox; Jennifer P. Morton; Marina Pajic; Paul Timpson
• Keywords: Priming (agriculture)

Fine-tuned manipulation of tumor tension and vasculature enhances response to chemotherapy impairs metastatic spread in pancreatic cancer.