Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats

• DOI: 10.1126/scitranslmed.aai8753
• Publication Date: 2017-12-20T19:14:04Z
• Authors: Danai Riga; Ioannis Kramvis; Maija K. Koskinen; Pieter van Bokhoven; Johanneke E. van ...; Tim S. Heistek; A. Jaap Timmerman; Pim van Nierop; Roel C. van der S...; Anton W. Pieneman; Anouk de Weger; Yvar van Mourik; Anton N. M. Schof...; Huib D. Mansvelder; Rhiannon M. Meredith; Witte J. G. Hooge...; August B. Smit; Sabine Spijker
• Keywords: Male; 0301 basic medicine; Imipramine; EMC OR-01; Radboud University Medical Center; Chondroitin ABC Lyase; Hippocampus; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; 03 medical and health sciences; SDG 3 - Good Health and Well-being; Interneurons; Memory; Journal Article; Animals; Cognitive Dysfunction; Rats, Wistar; Social Behavior; CA1 Region, Hippocampal; Depression; Neural Inhibition; Extracellular Matrix; Chondroitin Sulfate Proteoglycans; Chronic Disease; Synapses; Stress, Psychological

Alterations in the hippocampal extracellular matrix contribute to cognitive deficits in rats exhibiting a chronic depressive-like state after exposure to social defeat–induced persistent stress.