Inhalation of peptide-loaded nanoparticles improves heart failure

• DOI: 10.1126/scitranslmed.aan6205
• Publication Date: 2018-01-17T19:05:30Z
• Authors: Michele Miragoli; Paola Ceriotti; Michele Iafisco; Marco Vacchiano; Nicolò Salvarani; Alessio Alogna; Pierluigi Carullo; Gloria Belén Rami...; Tatiana Patrício; Lorenzo Degli Esp...; Francesca Rossi; Francesca Ravanetti; Silvana Pinelli; Rossella Alinovi; Marco Erreni; Stefano Rossi; Gianluigi Condorelli; Heiner Post; Anna Tampieri; Daniele Catalucci
• Keywords: Calcium Phosphates; Male; 0301 basic medicine; Swine; 610; heart failure; Administration, Inhalation, Animals, Calcium Phosphates, Drug Carriers, Echocardiography, Heart Failure, Male, Mice, Inbred C57BL, Nanoparticles, Peptides, Rats, Wistar, Swine; Mice; 03 medical and health sciences; calcium phosphate nanoparticles; therapeutic peptides; cardiovascular disease; Administration, Inhalation; myocardium; Animals; Rats, Wistar; Heart Failure; inhalation; Drug Carriers; Medicine (all); nanoparticle; drug-delivery; Rats; 3. Good health; Mice, Inbred C57BL; Echocardiography; drug delivery; Nanoparticles; Peptides

Inhalation delivers drug-loaded nanoparticles to the heart, improving cardiac function in murine and porcine models.