Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

• DOI: 10.1126/scitranslmed.aao5253
• Publication Date: 2019-01-03T00:15:40Z
• Authors: Wei Yang; Nicole M. Warrington; Sara J. Taylor; Paula Whitmire; Eduardo Carrasco; Kyle W. Singleton; Ningying Wu; Justin D. Lathia; Michael E. Berens; Albert H. Kim; Jill S. Barnholtz...; Kristin R. Swanson; Jingqin Luo; Joshua B. Rubin
• Keywords: Diagnostic Imaging; Male; 0301 basic medicine; Sex Characteristics; Magnetic Resonance Imaging; Disease-Free Survival; Isocitrate Dehydrogenase; 3. Good health; Cohort Studies; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Cell Line, Tumor; Mutation; Humans; Female; Glioblastoma; Transcriptome; 10. No inequality; Signal Transduction

Male and female glioblastomas are biologically distinct, and improving outcomes may require sex-specific approaches to treatment.