Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

• DOI: 10.1126/scitranslmed.aar3959
• Publication Date: 2018-10-03T18:10:47Z
• Authors: Amber L. Southwell; Holly B. Kordasie...; Douglas Langbehn; Niels H. Skotte; Matthew P. Parsons; Erika B. Villanueva; Nicholas S. Caron; Michael E. Østerg...; Lisa M. Anderson; Yuanyun Xie; Louisa Dal Cengio; Hailey Findlay-Black; Crystal N. Doty; Bethany Fitsimmons; Eric E. Swayze; Punit P. Seth; Lynn A. Raymond; C. Frank Bennett; Michael R. Hayden
• Keywords: Male; Primates; 0301 basic medicine; Dopamine and cAMP-Regulated Phosphoprotein 32; Huntingtin Protein; Behavior, Animal; Brain; Anxiety; Oligonucleotides, Antisense; Disease Models, Animal; 03 medical and health sciences; Cognition; Huntington Disease; Limbic System; Animals; Humans; Female; Mutant Proteins; Atrophy

Mutant huntingtin suppression with antisense oligonucleotides reverses cognitive impairments in a mouse model of Huntington’s disease.