An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products

• DOI: 10.1126/scitranslmed.aay0605
• Publication Date: 2020-04-22T23:11:15Z
• Authors: Marta de los Reye...; Antonie Lechner; Francesca Alessan...; Sina Bohnacker; Sonja Schindela; Aurélien Trompette; Pascal Haimerl; Dominique Thomas; Fiona Henkel; André Mourão; Arie Geerlof; Clarissa Prazeres...; Adam M. Chaker; Bernhard Brüne; Rolf Nüsing; Per-Johan Jakobsson; Wolfgang A. Nockher; Matthias J. Feige; Martin Haslbeck; Caspar Ohnmacht; Benjamin J. Marsland; David Voehringer; Nicola L. Harris; Carsten B. Schmid...; Julia Esser-von B...
• Keywords: Mediator

A helminth larval extract and its component Hpb glutamate dehydrogenase induce an anti-inflammatory mediator switch to suppress type-2 inflammation.