Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma

• DOI: 10.1126/scitranslmed.aay2163
• Publication Date: 2020-06-10T23:19:18Z
• Authors: Madi Y. Cissé; Samuel Pyrdziak; Nelly Firmin; Laurie Gayte; Maud Heuillet; Floriant Bellvert; Maryse Fuentes; Hélène Delpech; Romain Riscal; Giuseppe Arena; Frédéric Chibon; Sophie Le Gellec; Aurélie Maran-Gon...; Marie-Christine C...; Charles Theillet; Sébastien Carrere; Jean-Charles Portais; Laurent Le Cam; Laetitia K. Linares
• Keywords: 570; 0303 health sciences; 03 medical and health sciences; Serine; 610; Humans; Antineoplastic Agents; Proto-Oncogene Proteins c-mdm2; Liposarcoma; Tumor Suppressor Protein p53; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; 3. Good health

Chromatin-bound MDM2 regulates serine metabolism and nucleotide synthesis to sustain tumor growth in liposarcoma.