Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice

• DOI: 10.1126/scitranslmed.aay7896
• Publication Date: 2021-03-31T19:07:14Z
• Authors: Naofumi Ito; M. Asrafuzzaman R...; Shah Adil Ishtiya...; Satoko Hattori; Yonehiro Kanemura; Hiroshi Kiyonari; Takaya Abe; Yasuhide Furuta; Yohei Shinmyo; Naoko Kaneko; Yuki Hirota; Giuseppe Lupo; Jun Hatakeyama; Felemban Athary A...; Mohammad Badrul Anam; Masahiro Yamaguchi; Toru Takeo; Hirohide Takebayashi; Minoru Takebayashi; Yuichi Oike; Naomi Nakagata; Kenji Shimamura; Michael J. Holtzman; Yoshiko Takahashi; Francois Guillemot; Tsuyoshi Miyakawa; Kazunobu Sawamoto; Kunimasa Ohta
• Keywords: Mice, Knockout; 0301 basic medicine; Neurogenesis; Mice; 03 medical and health sciences; Neural Stem Cells; Tsukushi, hydrocephalus, neurogenesis; Animals; Humans; Proteoglycans; Stem Cell Niche; Cell Proliferation; Hydrocephalus

Tsukushi loss in the mouse subventricular zone led to altered neurogenesis and hydrocephalus.