CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice

• DOI: 10.1126/scitranslmed.aaz8664
• Publication Date: 2020-08-26T23:13:23Z
• Authors: Chih-Hao Wang; Morten Lundh; Accalia Fu; Rókus Kriszt; Tian Lian Huang; Matthew D. Lynes; Luiz O. Leiria; Farnaz Shamsi; Justin Darcy; Bennett P. Greenwood; Niven R. Narain; Vladimir Tolstikov; Kyle L. Smith; Brice Emanuelli; Young-Tae Chang; Susan Hagen; Nika N. Danial; Michael A. Kiebish; Yu-Hua Tseng
• Keywords: 0301 basic medicine; HOMEOSTASIS; WHITE ADIPOSE-TISSUE; Mice, Obese; Diet, High-Fat; Mice; 03 medical and health sciences; Adipose Tissue, Brown; Animals; Humans; Clustered Regularly Interspaced Short Palindromic Repeats; Obesity; NITRIC-OXIDE SYNTHASE; COLD; HEMOGLOBIN; GENE-EXPRESSION; Metabolic Syndrome; 2. Zero hunger; INSULIN-RESISTANCE; ENERGY-EXPENDITURE; Thermogenesis; 3. Good health; Adipocytes, Brown; FAT; SKELETAL-MUSCLE; Energy Metabolism

Human white adipocytes engineered to express UCP1 activate endogenous BAT and protect against diet-induced obesity when transplanted into mice.