iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension

• DOI: 10.1126/scitranslmed.aba6480
• Publication Date: 2021-05-05T19:13:25Z
• Authors: Mingxia Gu; Michele Donato; Minzhe Guo; Neil Wary; Yifei Miao; Shuai Mao; Toshie Saito; Shoichiro Otsuki; Lingli Wang; Rebecca L. Harper; Silin Sa; Purvesh Khatri; Marlene Rabinovitch
• Keywords: 0301 basic medicine; Pulmonary Arterial Hypertension; Hypertension, Pulmonary; Induced Pluripotent Stem Cells; Drug Evaluation, Preclinical; Endothelial Cells; Pulmonary Artery; Tyrphostins; Rats; 3. Good health; Disease Models, Animal; 03 medical and health sciences; Quality of Life; Animals; Humans; Computer Simulation; Cyclic AMP Response Element-Binding Protein; Cell Proliferation

Drug screening for improved function and transcriptomics of iPSC-derived endothelial cells from patients with pulmonary hypertension reveals AG1296.