A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity

• DOI: 10.1126/scitranslmed.aba7308
• Publication Date: 2021-01-27T20:16:39Z
• Authors: Huihui Zhang; Fanlin Li; Jiang Cao; Xin Wang; Hai Cheng; Kunming Qi; Gang Wang; Kailin Xu; Junnian Zheng; Yang-Xin Fu; Xuanming Yang
• Keywords: Mice; Phosphatidylinositol 3-Kinases; 0303 health sciences; 03 medical and health sciences; Receptors, Chimeric Antigen; Cell Line, Tumor; T-Lymphocytes; Receptors, Antigen, T-Cell; Animals; Humans; Immunotherapy, Adoptive; Xenograft Model Antitumor Assays

Integrating full-length OX40 boosts the antitumor activity of CAR-T cells.