Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

• DOI: 10.1126/scitranslmed.abc0497
• Publication Date: 2021-10-21T20:40:13Z
• Authors: Pooja Panwalkar; Benita Tamrazi; Derek Dang; Chan Chung; Stefan Sweha; Siva Kumar Natarajan; Matthew Pun; Jill Bayliss; Martin P. Ogrodzi...; Drew Pratt; Brendan Mullan; Debra Hawes; Fusheng Yang; Chao Lu; Benjamin R. Sabari; Abhinav Achreja; Jin Heon; Olamide Animasahun; Marcin Cieslik; Christopher Dunham; Stephen Yip; Juliette Hukin; Joanna J. Phillips; Miriam Bornhorst; Andrea M. Griesinger; Andrew M. Donson; Nicholas K. Foreman; Hugh J. L. Garton; Jason Heth; Karin Muraszko; Javad Nazarian; Carl Koschmann; Li Jiang; Mariella G. Filbin; Deepak Nagrath; Marcel Kool; Andrey Korshunov; Stefan M. Pfister; Richard J. Gilber...; C. David Allis; Arul M. Chinnaiyan; Sophia Y. Lunt; Stefan Blüml; Alexander R. Judkins; Sriram Venneti
• Keywords: Metabolic pathway; Ependymoma; Epigenesis; Posterior fossa

Childhood posterior fossa group A ependymomas demonstrate integrated metabolic and epigenetic pathways that can be disrupted by metformin.