Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

• DOI: 10.1126/scitranslmed.abc7804
• Publication Date: 2021-09-08T19:02:14Z
• Authors: Christian Hotz; Timothy R. Wagenaar; Friederike Gieseke; Dinesh S. Bangari; Michelle Callahan; Hui Cao; Jan Diekmann; Mustafa Diken; Christian Grunwitz; Andy Hebert; Karl Hsu; Marie Bernardo; Katalin Karikó; Sebastian Kreiter; Andreas N. Kuhn; Mikhail Levit; Natalia Malkova; Serena Masciari; Jack Pollard; Hui Qu; Sue Ryan; Abderaouf Selmi; Julia Schlereth; Kuldeep Singh; Fangxian Sun; Bodo Tillmann; Tatiana Tolstykh; William Weber; Lena Wicke; Sonja Witzel; Qunyan Yu; Yu-An Zhang; Gang Zheng; Joanne Lager; Gary J. Nabel; Ugur Sahin; Dmitri Wiederschain
• Keywords: 0303 health sciences; 03 medical and health sciences; Neoplasms; Cytokines; Humans; RNA, Messenger; 3. Good health

Local immunotherapy with an mRNA mixture encoding four cytokines mobilizes a systemic antitumor response and promotes tumor eradication.