Neuronal delivery of antibodies has therapeutic effects in animal models of botulism

• DOI: 10.1126/scitranslmed.abd7789
• Publication Date: 2021-01-06T20:12:07Z
• Authors: Patrick M. McNutt; Edwin J. Vazquez-...; Luis Tenezaca; Celinia A. Ondeck; Kyle E. Kelly; Mark Mangkhalakhili; James B. Machamer; Christopher A. An...; Elliot J. Glotfelty; Jaclyn Cika; Cesar H. Benjumea; Justin T. Whitfield; Philip A. Band; Charles B. Shoemaker; Konstantin Ichtch...
• Keywords: 0301 basic medicine; Mice; 03 medical and health sciences; Guinea Pigs; Models, Animal; Neurotoxins; Animals; Botulism; Botulinum Toxins, Type A; Single-Domain Antibodies; 3. Good health

Intraneuronal delivery of a therapeutic, single-domain antibody reverses botulism symptoms and increases survival of mice, guinea pigs, and monkeys.