CD4 + T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12

• DOI: 10.1126/scitranslmed.add6137
• Publication Date: 2023-03-15T17:58:18Z
• Authors: Hans-Joachim Paust; Ning Song; Donatella De Feo; Nariaki Asada; Selma Tuzlak; Yu Zhao; Jan-Hendrik Riedel; Malte Hellmig; Amirrtavarshni Si...; Anett Peters; Anna Kaffke; Alina Borchers; Ulrich O. Wenzel; Oliver M. Steinmetz; Gisa Tiegs; Elisabeth Meister; Matthias Mack; Christian Kurts; Sibylle von Vieti...; Maja T. Lindenmeyer; Elion Hoxha; Rolf A. K. Stahl; Tobias B. Huber; Stefan Bonn; Catherine Meyer-S...; Thorsten Wiech; Jan-Eric Turner; Burkhard Becher; Christian F. Krebs; Ulf Panzer
• Keywords: Monocyte

GM-CSF in glomerulonephritis Despite being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap knowledge, Paust et al . characterized pathological cells samples from patients with and mice disease. The authors found that CD4+ T producing granulocyte-macrophage colony-stimulating factor (GM-CSF) licensed monocytes to promote disease by matrix metalloproteinase 12 disrupting glomerular basement membrane. Targeting inhibit axis reduced severity mice, implicating cytokine as a potential therapeutic target for glomerulonephritis. —CM