SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma

• DOI: 10.1126/scitranslmed.adj7685
• Publication Date: 2024-05-15T17:58:51Z
• Authors: Iris S. Luk; Caroline M. Bridg...; Angela Yu; Liberalis D. Boila; Mariana Yáñez-Bar...; Aaron E. Lampano; Taylor S. Hulahan; Myriam Boukhali; Meena Kathiresan; Teresa Macarulla; Heidi L. Kenerson; Naomi Yamamoto; David Sokolov; Ian A. Engstrom; Lucas B. Sullivan; Paul D. Lampe; Jonathan A. Cooper; Raymond S. Yeung; Tian V. Tian; Wilhelm Haas; Supriya K. Saha; Sita Kugel
• Keywords: Isocitrate dehydrogenase

Intrahepatic cholangiocarcinoma (ICC) is an aggressive bile duct malignancy that frequently exhibits isocitrate dehydrogenase (