Changing Pattern of Plasmodium falciparum pfmdr1 Gene Polymorphisms in Southern Rwanda

• DOI: 10.1128/aac.00901-21
• Publication Date: 2021-07-06T19:27:30Z
• Authors: Welmoed van Loon; Clara Bergmann; Felix Habarugira; Costanza Tacoli; Darius Savelsberg; Rafael Oliveira; Djibril Mbarushimana; Jules Ndoli; Augustin Sendegeya; Claude Bayingana; Frank P. Mockenhaupt
• Keywords: Lumefantrine

Plasmodium falciparum multidrug resistance-1 gene ( pfmdr1 ) polymorphisms associate with altered antimalarial susceptibility. Between 2010 and 2018/2019, we observed that the prevalence of wild-type allele N86 combination NYD increased 10-fold (4% versus 40%) more than 2-fold (18% 44%), respectively.