Successful Treatment of Disseminated Disease Due to Highly Resistant Aspergillus calidoustus with a Novel Antifungal Therapy

• DOI: 10.1128/aac.02206-21
• Publication Date: 2021-12-21T01:11:59Z
• Authors: Jose F. Camargo; Ra’ed Jabr; Anthony D. Anderson; Lazaros Lekakis; Meilin Diaz-Paez; Laurence M. Briski; Mohammed Raja; Michele I. Morris; Krishna V. Komanduri; Denise Pereira
• Keywords: hematopoietic cell transplant; Antifungal Agents; APX001; Clinical Sciences; Aspergillus calidoustus; Microbiology; Vaccine Related; 03 medical and health sciences; Rare Diseases; Aspergillosis; Humans; Transplantation; 0303 health sciences; Biomedical and Clinical Sciences; Prevention; Hematopoietic Stem Cell Transplantation; Pharmacology and Pharmaceutical Sciences; Biological Sciences; Medical microbiology; Stem Cell Research; 3. Good health; Emerging Infectious Diseases; Infectious Diseases; Pharmacology and pharmaceutical sciences; Aspergillus; Medical Microbiology; Antimicrobial Resistance; Infection

Invasive aspergillosis is the most common invasive mold infection following a hematopoietic cell transplant. Widespread use of antifungal prophylaxis has led to increasing incidence cryptic Aspergillus species. calidoustus one those emerging species and notorious for multidrug resistance antifungals. Here, we report case disseminated A. in stem transplant recipient who was successfully treated with combination therapy that included novel antifungal.