Prophylaxis with Teicoplanin and Cefuroxime Reduces the Rate of Prosthetic Joint Infection after Primary Arthroplasty

• DOI: 10.1128/aac.03949-14
• Publication Date: 2014-11-18T05:07:10Z
• Authors: Eduard Tornero; Sebastian García-...; Juan C. Martínez-...; Guillem Bori; Jordi Bosch; Laura Morata; Marta Sala; Misericordia Basora; Josep Mensa; Alex Soriano
• Keywords: Cefuroxime; Teicoplanin; Discontinuation

ABSTRACT The aim of this study was to compare the prosthetic joint infection (PJI) rate after total arthroplasty in two consecutive periods treatment with different antibiotic prophylaxes: cefuroxime versus plus teicoplanin. We retrospectively reviewed 1,896 patients who underwent hip or knee between March 2010 and February 2013. From August 2011, received 1.5 g during induction anesthesia another 2 h later (the C group). September 800 mg teicoplanin added CT Throughout period studied, there were no variations pre- postoperative protocols. Univariate multivariate analyses performed evaluate independent predictors PJI. There 995 (55.7%) group 791 (44.3%) group. Patients had a significantly lower PJI than (1.26% 3.51%, P = 0.002). infections due Staphylococcus aureus (0% 1.6% group, < 0.001). A stepwise forward Cox regression model identified male sex (hazard ratio [HR], 3.85; 95% confidence interval [CI], 2.09 7.18), body mass index ≥35 kg/m (HR, 2.93; CI, 1.37 6.27), presence lung disease 2.46; 1.17 5.15), red blood cell transfusion 3.70; 1.89 7.23) be variables associated higher risk addition 0.35; 0.17 0.74). In conclusion, primary significant reduction global caused by Gram-positive bacteria.