Investigation of Metronidazole Use during Pregnancy and Adverse Birth Outcomes

• DOI: 10.1128/aac.06477-11
• Publication Date: 2012-07-03T02:37:25Z
• Authors: Catherine A. Koss; Dana C. Baras; Sandra D. Lane; Richard Aubry; Michele Marcus; Lauri E. Markowitz; Emilia H. Koumans
• Keywords: Premature birth

To assess whether treatment with metronidazole during pregnancy is associated preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort women delivering at urban New York State hospital. Of 2,829 singleton/mother pairs, 922 (32.6%) mothers were treated for clinical indications, 348 (12.3%) the first trimester 553 (19.5%) in second third trimester. There 333 (11.8%) births, 262 (9.3%) infants 52 (1.8%) anomalies. In multivariable analysis, no association was found between (odds ratio [OR], 1.02 [95% confidence interval [CI], 0.80 to 1.32]), weight (OR, 1.05 CI, 0.77 1.43]), anomalies 0.86 [0.30 2.45]). We later trimesters