Effect of Grapefruit Juice on Clarithromycin Pharmacokinetics

• DOI: 10.1128/aac.42.4.927
• Publication Date: 2018-10-09T00:31:10Z
• Authors: Kit L. Cheng; Anne N. Nafziger; Charles A. Peloquin; Guy W. Amsden
• Keywords: Adult; Male; Citrus; Cross-Over Studies; Anti-Bacterial Agents; Mixed Function Oxygenases; 3. Good health; Beverages; Food-Drug Interactions; 03 medical and health sciences; 0302 clinical medicine; Cytochrome P-450 Enzyme System; Area Under Curve; Clarithromycin; Cytochrome P-450 CYP3A; Humans; Female

ABSTRACT

To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 ± 35 versus 148 ± 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 ± 38 min versus 173 ± 85; P = 0.01) but did not affect other pharmacokinetic parameters.