RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus

• DOI: 10.1128/aac.44.11.3163-3166.2000
• Publication Date: 2002-07-27T10:06:42Z
• Authors: Alexander O'Neill; Brunello Oliva; Christopher Storey; Anthony Hoyle; Colin Fishwick; Ian Chopra
• Keywords: rpoB

ABSTRACT A collection of rifampin-resistant mutants Staphylococcus aureus with characterized RNA polymerase β-subunit ( rpoB ) gene mutations was cross-screened against a number other inhibitors to correlate susceptibility specific genotypes. The were cross-resistant streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, ripostatin retained activity the mutants. second group may be interest as drug development candidates.