A between-Species Comparison of Antimicrobial Resistance in Enterobacteria in Fecal Flora

• DOI: 10.1128/aac.44.6.1479-1484.2000
• Publication Date: 2002-07-27T09:56:57Z
• Authors: Monica Österblad; Antti Hakanen; Raija Manninen; Tiina Leistevuo; Reijo Peltonen; Olli Meurman; Pentti Huovinen; Pirkko Kotilainen
• Keywords: Klebsiella

ABSTRACT Enterobacteria in fecal flora are often reported to be highly resistant. Escherichia coli is the main species; resistance data on other species rare. To assess effect of host's environment, antimicrobial was determined family Enterobacteriaceae from three populations: healthy people (HP)( n = 125) with no exposure antimicrobials for 3 months preceding sampling, university hospital patients (UP) ( 159) wards where antibiotic use 112 defined daily doses (DDD)/bed/month, and geriatric long-term (LTP) 74) who used 1.8 DDD/bed/month. The mean length stay 5 days UP 22 LTP. isolates were identified at least genus level, MICs 16 determined. From hospital, clinical also collected. Resistance average two different per sample (range, 1 5) analyzed: 471 E. 261 spp. mainly found among ; even HP, 18% resistant or more groups, MIC patterns indicative transferable resistance. Other enterobacteria generally susceptible, little typically multiresistance. Clinical Klebsiella Enterobacter significantly than isolates. both hospitals mirrored use, but LTP those UP. Conditions permitting an efficient spread may have been important sustaining high levels carrier flora; rare absence selection.