In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

• DOI: 10.1128/aac.45.6.1746-1750.2001
• Publication Date: 2002-07-27T09:56:57Z
• Authors: Bruno Pradines; Christophe Rogier; Thierry Fusai; Joel Mosnier; William Daries; Eric Barret; Daniel Parzy
• Keywords: Roxithromycin; Spiramycin

ABSTRACT The in vitro activities of cyclines (tetracycline, doxycycline, minocycline, oxytetracycline, and rolitetracycline), macrolides (erythromycin, spiramycin, roxithromycin, lincomycin), quinolones (norfloxacin ofloxacin), rifampin, thiamphenicol, tobramycin, metronidazole, vancomycin, phosphomycin, cephalosporins (cephalexin, cefaclor, cefamandole, cefuroxime, ceftriazone, cefotaxime, cefoxitin) were evaluated on Plasmodium falciparum clones, using an isotopic, micro-drug susceptibility test. Only tetracyclines, macrolides, quinolones, rifampin demonstrated activity against P. , which increased after a prolonged exposure (96 or 144 h). In the presence iron (FeCl 3 ), only tetracyclines norfloxacin decreased. Their intraerythrocytic stages multidrug-resistant their efficacy vivo favor use antibiotics as antimalarial drugs. However, due to slow action fact that they act better contact, probably need be administered conjunction with rapidly acting drug, such short course chloroquine quinine.