Prevalence of Antibiotic Resistance Genes among Human Gut-Derived Bifidobacteria

• DOI: 10.1128/aem.02894-16
• Publication Date: 2016-11-19T03:25:36Z
• Authors: Sabrina Duranti; Gabriele Andrea L...; Leonardo Mancabelli; Francesca Turroni; Christian Milani; Marta Mangifesta; Chiara Ferrario; Rosaria Anzalone; Alice Viappiani; Douwe van Sinderen; Marco Ventura
• Keywords: Resistome; Human gastrointestinal tract; Colonisation resistance

The microbiota of the human gastrointestinal tract (GIT) may regularly be exposed to antibiotics, which are used prevent and treat infectious diseases caused by bacteria fungi. Bacterial communities gut retain a reservoir antibiotic resistance (AR) genes, therapy thus positively selects for those microorganisms that harbor such genetic features, causing modulation. During first months following birth, bifidobacteria represent some most dominant components microbiota, although little is known about their AR gene complement (or resistome). In current study, we assessed resistome Bifidobacterium genus based on phenotypic genotypic data members all currently recognized bifidobacterial (sub)species. Moreover, comparison between metagenome sets from adults infants shows community present at week birth possesses reduced arsenal compared in infant population subsequent weeks year life. Our findings reinforce concept early more susceptible disturbances treatment than developed later life stage.The spread antibiotics among bacterial has represented major concern since discovery last century. risk transfer genes been extensively investigated due its relevance health. contrast, there only limited information available commensal as bifidobacteria, widely exploited food industry health-promoting or probiotic ingredients. explored occurrence genomes evaluated mobility other microorganisms.