Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis

• DOI: 10.1128/cdli.4.6.719-722.1997
• Publication Date: 2020-01-06T18:40:30Z
• Authors: T S Steiner; C A Flores; T T Pizarro; R L Guerrant
• Keywords: Lactoferrin; Proinflammatory cytokine

Twenty-two patients with Clostridium difficile colitis as determined by positive enzyme immunoassay for toxin A were evaluated fecal inflammatory markers and their relationship to the severity of illness. Fourteen 22 specimens lactoferrin (FLF), titers from 1:50 1:800. Nine 10 stools tested had ratios interleukin-1beta (IL-1beta) IL-1 receptor antagonist (IL-1ra) >0.01. Seventeen also elevated IL-8 concentrations, 12 14 IL-1beta concentrations. review 18 available patient records revealed that IL-1beta/IL-1ra ratios, FLF significantly higher in moderate severe disease than mild disease. These findings suggest proinflammatory effects C. may directly influence clinical characteristics human